Centenary State Historic Site commemorates Centenary College, an all-male college (circa 1839-1908) which was previously located on today's historic site. With the college closed during the Civil War, both the Union and Confederate forces made use of the school structures for hospitals and/or area headquarters. The structures which remain on-site were the West Wing and the residence of a professor.

The site offers period rooms, tours, educational programs, and picnic facilities.