The Corpus Christi Museum of Science and History presents the story of a cultural crossroads of the New World. With a confluence of natural history, science, people, and environments, the South Texas area has served as a stage for the ongoing discovery of the Americas. The museum's exhibits explore natural history and South Texas history, and include full-size, functioning reconstructions of Christopher Columbus's three ships.

The museum offers exhibits, self-guided and guided tours for school groups, tours of the Columbus Ships, traveling trunks available for rent, and occasional recreational and educational events.